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For example, individuals with loss-of-function mutations of the DPP1 gene develop prepubertal aggressive periodontitis, Papillon-Lefvre syndrome (PLS) ( In this review, we provide an overview of DPP1, its functional biochemical properties, the consequences of its inactivation and deficiency, and NSP pathophysiology in a variety of disorders

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Fatty acid synthase and ACC are transcriptionally regulated by E2 treatment in HepG2 cells (50, 51), and both ER- and GPER1-knockout rodent models display upregulated hepatic expression of genes involved in lipid biosynthesis (27)

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